MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.

Francesca ManciniEmanuela TeveroniGiusy Di ConzaValentina MonteleoneIvan ArisiMarsha PellegrinoMarianna ButtarelliLuisa PieroniMara D'OnofrioAndrea UrbaniAlfredo PontecorviMassimiliano MazzoneFabiola Moretti

Published in: Molecular cancer (2017)

Overall, these data identify MDM4 as a nutrient-sensor able to inhibit mTORC1 and highlight its metabolism-related tumor-suppressing function.

Keyphrases

electronic health record
signaling pathway
big data
machine learning
data analysis