4-Methylumbelliferone suppresses hyaluronan and adipogenesis in primary cultured orbital fibroblasts from Graves' orbitopathy.

Yeonjung YoonMin Kyung ChaeEun Jig LeeJin Sook Yoon

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

4-MU represents a promising new therapeutic agent for GO based on its ability to inhibit hyaluronan production and adipogenesis, without decreasing cell viability.

Keyphrases

high fat diet induced
signaling pathway
endothelial cells
extracellular matrix
insulin resistance
type diabetes
adipose tissue