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Diabetes Mellitus and Ischemic Heart Disease: The Role of Ion Channels.

Paolo SeverinoAndrea D'AmatoLucrezia NettiMariateresa PucciMarialaura De MarchisRaffaele PalmirottaMaurizio VolterraniMassimo ManconeFrancesco Fedele
Published in: International journal of molecular sciences (2018)
Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic patients have mainly coronary stenosis obstructing blood flow to the myocardium; others present with coronary microvascular disease with an absence of plaques in the epicardial vessels. Ion channels acting in the cross-talk between the myocardial energy state and coronary blood flow may play a role in the pathophysiology of IHD in diabetic patients. In particular, some genetic variants for ATP-dependent potassium channels seem to be involved in the determinism of IHD.
Keyphrases
  • blood flow
  • coronary artery disease
  • coronary artery
  • cardiovascular disease
  • left ventricular
  • aortic stenosis
  • glycemic control
  • heart failure
  • metabolic syndrome
  • transcatheter aortic valve replacement
  • weight loss