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The effect of oral bisphosphonate therapy on vertebral morphometry and fractures in patients with Duchenne muscular dystrophy and glucocorticoid-induced osteoporosis.

Nat NasomyontCuixia TianLindsey HornungJane KhouryPaul M HochwaltJoshua Cole TildenBrenda L WongMeilan M Rutter
Published in: Muscle & nerve (2021)
We observed stable prevalence of vertebral fractures and no change in severity by Genant grade in most vertebrae for up to 5 years of treatment. Oral BP may mitigate development or progression of vertebral fractures and be beneficial for secondary prevention of glucocorticoid-induced osteoporosis in this population.
Keyphrases
  • bone mineral density
  • duchenne muscular dystrophy
  • postmenopausal women
  • high glucose
  • diabetic rats
  • body composition
  • drug induced
  • risk factors
  • endothelial cells
  • bone marrow
  • cell therapy