Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA.
Danny Ka-Ho WongWai-Kay SetoKa-Shing CheungChun-Kong ChongFung-Yu HuangJames FungChing-Lung LaiMan Fung YuenPublished in: Liver international : official journal of the International Association for the Study of the Liver (2017)
Serum HBcrAg is a reliable surrogate marker for intrahepatic cccDNA. HBcrAg could be a very sensitive marker to reflect the cccDNA content and persistence of disease even with the cccDNA levels below the detection limit of assays.