Probing the flux of mitochondrial potassium using an azacrown-diketopyrrolopyrrole based highly sensitive probe.

G Dinesh KumarMarzena BanasiewiczAntoni WrzosekRafal P Kampa Manon H E BousquetDamian KusyDenis JacqueminAdam SzewczykDaniel T Gryko

Published in: Chemical communications (Cambridge, England) (2022)

The diketopyrrolopyrrole bearing an aza-18-crown-6 as a binding unit as well as a PPh 3 + group is highly sensitive towards K + and localizes selectively in mitochondria of cardiac H9C2 cells. Fast efflux/influx of mitochondrial K + can be observed upon stimulation with nigericin.

Keyphrases

oxidative stress
induced apoptosis
living cells
fluorescent probe
cell cycle arrest
cell death
single molecule
molecularly imprinted
left ventricular
quantum dots
signaling pathway
molecular dynamics simulations
dna binding
binding protein
cell proliferation