Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis.
Alexandra van WijnenFranca PetrovMichelle MaiwormStefan FrischChristian FoerchElke HattingenHelmuth SteinmetzJohannes C KleinRalf DeichmannMarlies WagnerRené-Maxime GracienPublished in: European radiology (2019)
• The goal of the presented study was to investigate cortical changes in RRMS/CIS and their relation to the cognitive status, using multiparametric quantitative MRI. • Cortical T2, T2*, and PD increases observed in patients appeared heterogeneous across the cortex and their distribution differed between the parameters. • Vertex-wise correlation of T2 with neuropsychological scores revealed specific patterns of cortical changes being related to distinct cognitive deficits.
Keyphrases
- multiple sclerosis
- end stage renal disease
- magnetic resonance imaging
- contrast enhanced
- ejection fraction
- high resolution
- newly diagnosed
- white matter
- chronic kidney disease
- peritoneal dialysis
- disease activity
- diffusion weighted imaging
- single cell
- prognostic factors
- computed tomography
- functional connectivity
- rheumatoid arthritis
- magnetic resonance
- patient reported outcomes
- mass spectrometry