Login / Signup

Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery.

Yupeng WangLina WangBin LiYanxiang ChengDongfang ZhouXuesi ChenXiabin JingYubin Huang
Published in: ACS macro letters (2017)
Hollow vesicles self-assembled from amphiphilic copolymers are of great interest in biomedicine field as drug and protein carriers. Efficient preparation of polymeric vesicles with high stability in vivo is highly desirable. Herein, a novel cooperative self-assembly of two graft copolymers (GCPs) with reversed hydrophilic-hydrophobic segments is investigated to achieve morphology control for biomedical application. Interestingly, nanosized vesicles are obtained for the binary system with relatively high hydrophilic fraction ( f hydrophilic , ∼60%), contrary to what is found in its single-component counterpart. The cooperative self-assembly endowed the hybrid vesicles with excellent resistance to protein adsorption, prolonged blood circulation time, as well as low leakage of hydrophilic drugs/proteins. Furthermore, the biological activity of the protein is well preserved inside the cooperative vesicles, making it a promising candidate as the protein carrier.
Keyphrases
  • liquid chromatography
  • protein protein
  • drug delivery
  • mass spectrometry
  • ionic liquid
  • risk assessment
  • highly efficient