Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells.

Ping LiuWen HuangYirui DingJianbing WuZhuangzhuang LiangZhangjian HuangWeiping XieHui Kong

Published in: Drug design, development and therapy (2021)

FDCA ameliorates hypoxia-induced PASMC dysfunction by inhibiting both Ca2+/CaMK and Rho-kinase signaling pathways, as well as maintaining mitochondrial homeostasis, thus alleviating SuHx-induced PAH.

Keyphrases

pulmonary arterial hypertension
pulmonary hypertension
oxidative stress
signaling pathway
protein kinase
pulmonary artery
diabetic rats
mouse model
high glucose
tyrosine kinase
induced apoptosis
drug induced
polycyclic aromatic hydrocarbons
cell proliferation
stress induced