Autophagy-mediated degradation of NOTCH1 intracellular domain controls the epithelial to mesenchymal transition and cancer metastasis.

Sahib ZadaJin Seok HwangTrang Huyen LaiTrang Minh PhamMahmoud AhmedOmar ElashkarWanil KimDeok Ryong Kim

Published in: Cell & bioscience (2022)

These findings suggest that the cellular level of NICD is regulated by autophagy during cancer progression and that targeting autophagy-dependent NICD/SNAI1 degradation could be a strategy for the development of cancer therapeutics.

Keyphrases

papillary thyroid
cell death
squamous cell
signaling pathway
endoplasmic reticulum stress
oxidative stress
squamous cell carcinoma
cell proliferation
young adults