The mitochondrial stress-induced protein carboxyl-terminal alanine and threonine tailing (msiCAT-tailing) promotes glioblastoma tumorigenesis by modulating mitochondrial functions.

Ting CaiBei ZhangEsha ReddyYuanna WuYinglu TangIsha MondalJerry WangWinson S HoRongze Olivia LuZhihao Wu

Published in: bioRxiv : the preprint server for biology (2024)

The RQC pathway is disturbed in glioblastoma (GBM) cellsmsiCAT-tailing on ATP5α elevates mitochondrial membrane potential and inhibits MPTP openingmsiCAT-tailing on ATP5α inhibits drug-induced apoptosis in GBM cellsInhibition of msiCAT-tailing impedes overall growth of GBM cells.

Keyphrases

induced apoptosis
oxidative stress
stress induced
signaling pathway
endoplasmic reticulum stress
emergency department
pi k akt
amino acid
adverse drug