Cyclosporine A loaded brain targeting nanoparticle to treat cerebral ischemia/reperfusion injury in mice.
Daozhou LiuQifeng JiYing ChengMiao LiuBangle ZhangQibing MeiMenglei HuanSi-Yuan ZhouPublished in: Journal of nanobiotechnology (2022)
CsA@HFn showed a significant therapeutic effect on cerebral ischemia/reperfusion injury by alleviating the apoptosis of neuron, nerve inflammation and the damage of BBB in ischemic area. CsA@HFn has great potential in the treatment of ischemic stroke.
Keyphrases
- oxidative stress
- cerebral ischemia
- subarachnoid hemorrhage
- blood brain barrier
- cancer therapy
- drug delivery
- brain injury
- endoplasmic reticulum stress
- atrial fibrillation
- white matter
- cell death
- high fat diet induced
- type diabetes
- cerebral blood flow
- resting state
- metabolic syndrome
- adipose tissue
- peripheral nerve
- cell proliferation