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High false discovery rate of the Architect anti-HCV screening test in blood donors in Uganda and evaluation of an algorithm for confirmatory testing.

Olivia LuceySusan AcanaPeter Olupot-OlupotRita MuhindoRonald AyikobuaSophie UyogaDorothy Kyeyune-ByabazaireGraham CookeKathryn Maitland
Published in: Vox sanguinis (2022)
The Architect anti-HCV assay has a very high false discovery rate in Ugandan BTSs, leading to excessive blood disposal. Pre-analytical factors likely contribute to this. An introduction of confirmatory testing using an algorithm based on S/CO ratio evaluation could limit unnecessary blood wastage and donor deferral.
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