A diagnosis of late-onset Myasthenia gravis unmasked by topical antibiotics.
Nooreen HussainDanish HaqueSubramanyam ChittiveluPublished in: Journal of community hospital internal medicine perspectives (2018)
Myasthenia Gravis (MG) is a disorder of the neuromuscular junction (NMJ) that manifests as fluctuating fatiguable weakness of the muscles. There are many factors that can exacerbate myasthenia symptoms including a variety medications and drugs, systemic illness, and pregnancy. A number of medications have been implicated in exacerbating MG symptoms, including aminoglycosides. We present a case of an elderly female with newly diagnosed MG following the use of tobramycin eye drops for 3 days. There have been limited reports in the literature of topical medications that exacerbate MG symptoms. Clinicians prescribing tobramycin eye drops (or other associated medications) should have a high index of suspicion of MG as early discontinuation and therapy will limit long-term morbidity and mortality in these patients.
Keyphrases
- myasthenia gravis
- newly diagnosed
- late onset
- end stage renal disease
- early onset
- chronic kidney disease
- systematic review
- primary care
- emergency department
- preterm birth
- prognostic factors
- peritoneal dialysis
- stem cells
- palliative care
- pregnant women
- patient reported outcomes
- adverse drug
- depressive symptoms
- drug induced
- pregnancy outcomes