What can we learn from the islet of Joslin Medalists?

Published in: Journal of diabetes investigation (2020)

This commentary refers to the recent study of Joslin Medalists that showed evidence of residual endocrine cells still functioning in response to glucose stimuli. Islet pathology showed the ongoing remodeling influenced by autoimmune attack and glucose toxicity. The results showed the presence of functional endocrine cells that contribute to the longevity of patients with type 1 diabetes.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
multiple sclerosis
blood glucose
endoplasmic reticulum stress
cell death
signaling pathway
metabolic syndrome
weight loss