Axon-Myelin Unit Blistering as Early Event in MS Normal Appearing White Matter.
Antonio LuchicchiBert A 't HartIrene FrigerioAnne-Marie van DamLaura PernaHerman L OfferhausPeter K StysGeert J SchenkJeroen J G GeurtsPublished in: Annals of neurology (2021)
Collectively, the impaired interaction of myelin and axons potentially leads to myelin disintegration. Conceptually, the ensuing release of (post-translationally modified) myelin antigens may elicit a subsequent immune attack in MS. ANN NEUROL 2021;89:711-725.