Pre-treatment HIV-1 drug resistance in antiretroviral therapy-naive adults in Eastern Africa: a systematic review and meta-analysis.

Alex J NtamatungiroJuliana KaguraMaja WeisserJoel Msafiri Francis

Published in: The Journal of antimicrobial chemotherapy (2022)

We observed a moderate overall PDR prevalence among new ART initiators in this study. PDR to NNRTIs is more prevalent, underscoring the importance of the current WHO recommendation for replacement of NNRTIs by INSTIs. PDR to NRTIs was low but notable, which warrants continuous surveillance of pre-existing resistance to the dolutegravir co-administered NRTI in Eastern Africa.

Keyphrases

antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv positive
hiv infected patients
hiv aids
south africa
public health
risk factors
high intensity
hepatitis c virus