Prognostic significance of age in 5631 patients with Wilms tumour prospectively registered in International Society of Paediatric Oncology (SIOP) 93-01 and 2001.
Janna A HolM I Lopez-YurdaHarm D R van TinterenM Van GrotelJ GodzinskiG VujanicF OldenburgerB De CamargoGema L Ramirez-VillarC BergeronK Pritchard-JonesNorbert GrafM M Van den Heuvel-EibrinkPublished in: PloS one (2019)
Although optimal age cutoffs could not be identified, we demonstrated the prognostic significance of age as well as previously described cutoffs for EFS (2 and 4 years) and OS (4 years) in children with WT treated with pre-operative chemotherapy. These findings encourage the consideration of age in the design of future SIOP-RTSG protocols.