Alterations in plasma proteome during acute COVID-19 and recovery.
Maciej SuskiAgnieszka OlszaneckaAneta StachowiczAnna KiepuraMichał TerleckiJózef MadejMarek RajzerRafał OlszaneckiPublished in: Molecular medicine (Cambridge, Mass.) (2024)
In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
Keyphrases
- coronavirus disease
- cardiovascular events
- sars cov
- end stage renal disease
- respiratory syndrome coronavirus
- coronary artery disease
- newly diagnosed
- chronic kidney disease
- cardiovascular disease
- ejection fraction
- peritoneal dialysis
- liver failure
- prognostic factors
- cancer therapy
- respiratory failure
- intensive care unit
- hepatitis b virus
- drug induced
- human health
- small molecule
- amino acid
- aortic dissection