HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients.
Óscar BrochadoIsidoro MartínezJuan BerenguerLuz MedranoJuan González-GarcíaMaría Ángeles Jiménez-SousaAna CarreroVíctor HontañónJordi NavarroJosep M GuardiolaAmanda Fernández-RodríguezSalvador Resino Garcíanull nullPublished in: Journal of biomedical science (2021)
HIV/HCV-coinfected patients who eradicated hepatitis C with IFN-based therapy showed profound gene expression changes after achieving sustained virological response. The altered pathways were related to inflammation and liver-related complications, such as non-alcoholic fatty liver disease and hepatocellular carcinoma, underscoring the need for active surveillance for these patients.
Keyphrases
- gene expression
- hepatitis c virus
- end stage renal disease
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- ejection fraction
- newly diagnosed
- chronic kidney disease
- dna methylation
- hiv positive
- immune response
- prognostic factors
- oxidative stress
- hiv testing
- peritoneal dialysis
- patient reported outcomes
- patient reported
- south africa
- men who have sex with men
- helicobacter pylori