Uric acid effects on glutathione metabolism estimated by induction of glutamate-cysteine ligase, glutathione reductase and glutathione synthetase in mouse J744A.1 macrophage cell line.
Deyana G VankovaYoana Kiselova-KanevaDiana IvanovaPublished in: Folia medica (2023)
Elevated plasma levels of uric acid (UA) are considered an independent risk factor for hypertension, diabetes, cardiovascular disease, endothelial and vascular damage, obesity, and metabolic syndrome. Even physiological concentrations of soluble UA have been proved to induce gene expression of macrophage-secreted inflammatory cytokines and stimulate production of reactive oxygen species in mature adipocytes. UA is also described as a powerful endogenous plasma antioxidant, which reveals a paradox of duality for this parameter.
Keyphrases
- uric acid
- metabolic syndrome
- cardiovascular disease
- gene expression
- adipose tissue
- reactive oxygen species
- insulin resistance
- type diabetes
- oxidative stress
- cardiovascular risk factors
- blood pressure
- high fat diet induced
- dna methylation
- weight loss
- endothelial cells
- cardiovascular events
- living cells
- coronary artery disease
- fluorescent probe
- skeletal muscle
- arterial hypertension