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Pharmacogenomics of Coronary Artery Response to Intravenous Gamma Globulin in Kawasaki Disease.

Sadeep ShresthaHoward W WienerSabrina ChowdhuryHidemi KajimotoVinodh SrinivasasainagendraOlga A MamaevaUjval N BrahmbhattDolena LedeeYung LauLuz A PadillaJake Y ChenNagib DahdahHemant K TiwariMichael A Portman
Published in: medRxiv : the preprint server for health sciences (2024)
This pharmacogenomics study provides insights into the pathogenesis of CAA/L in IVIG-treated KD patients. We have identified multiple novel SNPs associated with CAA/L and related genes with potential functional implications. The study shows that genomics can help define the cause of CAA/L to guide management and improve risk stratification of KD patients.
Keyphrases
  • end stage renal disease
  • coronary artery
  • newly diagnosed
  • ejection fraction
  • chronic kidney disease
  • peritoneal dialysis
  • pulmonary artery
  • genome wide
  • low dose
  • pulmonary hypertension
  • adverse drug