Evaluation of Integrated HPV DNA as Individualized Biomarkers for the Detection of Recurrent CIN2/3 during Post-Treatment Surveillance.
Heike HoyerGrit MehlhornCornelia ScheungraberIngke HagemannChristine HirchenhainLinn WoelberClaudia StolteMonika HamplSarah ScherbringAgnieszka DeneckeJanina BartelsAndreas D EbertSabina MenederAnnett PetzoldTabitha HellerKarsten R HeidtkeElisabeth SchwarzFrederik A StuebsStefanie SchützeEva-Lena StangeAnna JaegerFranca MartignoniAnsgar DellmannAchim RodyPeter HillemannsTanja FehmKarl-Ulrich PetryGerd BöhmerBarbara SchmalfeldtPauline WimbergerMatthias W BeckmannIngo B RunnebaumMatthias DürstPublished in: Cancers (2021)
Although highly specific on its own vcj-PCR could not detect all recurrent CIN2/3. Possible reasons for this unexpected result may be multifocal lesions, intratumoral heterogeneity with respect to HPV integration and/or incident CIN.