Brain iron deposition and movement disorders in hereditary haemochromatosis without liver failure: A cross-sectional study.
Soumya SharmaSean Kumar SethiDavid ReeseSara GharabaghiKiran Kumar YerramsettyVinay Kumar PalutlaYongsheng ChenE Mark HaackeMandar S JogPublished in: European journal of neurology (2022)
Abnormal brain iron deposition can be demonstrated on imaging in all subjects with HH without liver failure. A significant proportion of these subjects manifest movement disorders. Peripheral iron measurements appear not to correlate with brain iron deposition. Therefore, routine neurological examination and quantitative brain iron imaging are recommended in all subjects with HH.
Keyphrases
- liver failure
- resting state
- white matter
- hepatitis b virus
- high resolution
- iron deficiency
- cerebral ischemia
- functional connectivity
- multiple sclerosis
- physical activity
- risk factors
- mass spectrometry
- clinical practice
- brain injury
- subarachnoid hemorrhage
- photodynamic therapy
- blood brain barrier
- fluorescence imaging