Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Louise KellyMohsen SeifiRuolin MaScott J MitchellUwe RudolphKirsten L ViolaWilliam L KleinJeremy J LambertJerome D SwinnyPublished in: Neuropathology and applied neurobiology (2020)
The data suggest a close association between AβO and α3-GABAA Rs in the LC of Alzheimer's patients, and their potential to dysregulate LC activity, thereby contributing to the spectrum of pathology of the LC-NA system in this condition.