Cognitive reserve attenuates age-related cognitive decline in the context of putatively accelerated brain ageing in schizophrenia-spectrum disorders.

Tamsyn E Van RheenenVanessa CropleyBirgitte FagerlundCassandra WannanJason BruggemannRhoshel K LenrootSuresh SundramCynthia Shannon WeickertThomas W WeickertAndrew ZaleskyChad A BousmanChristos Pantelis

Published in: Psychological medicine (2019)

In schizophrenia-spectrum illness, CR may negate ageing effects on fluid reasoning by buffering against pathologically exaggerated structural brain deterioration through some form of compensation. CR may represent an important modifier that could explain inconsistencies in brain structure - cognition outcomes in the extant literature.

Keyphrases

cognitive decline
white matter
resting state
mild cognitive impairment
bipolar disorder
functional connectivity
cerebral ischemia
multiple sclerosis
type diabetes
adipose tissue
skeletal muscle
weight loss