Relationship of Postoperative Pain and PONV after Minimally Invasive Surgery with the Serotonin Concentrations and Receptors' Gene Polymorphisms.
Natalia Ignaszak-KausAntoni J DulebaAleksandra MrozikiewiczGrażyna KurzawińskaAgata RóżyckaJan HaukeMichał GacaLeszek PawelczykPawel Piotr JagodzinskiPiotr JędrzejczakPublished in: Journal of personalized medicine (2021)
(1) Background: there is a steady increase in the number of procedures performed via minimally invasive surgery, which have many benefits, but post-operative nausea and vomiting (PONV) and significant pain are still a common problem (2) Methods: 300 infertile women (18-40 years old) undergoing minimal invasive surgery. Interventions: laparoscopy and hysteroscopy performing, evaluation of postoperative symptoms, serotonin concentrations assessment, identify genetic polymorphisms. (3) Results: serotonin concentrations were significantly lower among women who required opioids (p = 0.006). The presence of the GG genotype in the rs6318 polymorphism of the 5HTR2C gene had a protective effect on PONV (OR = 0.503; C.I. = [0.300-0.841]; p = 0.008), when the GG variant of the rs11214763 polymorphism of the 5HTR3B gene, when the risk of PONV was 1.65-fold higher (OR = 1.652; C.I. = [1.003-2.723]; p = 0.048). Pain intensity was significantly higher among women with GG genotype of the rs6296 polymorphism of the 5HTR1B gene (OR = 1.660; C.I. = [1.052-2.622]; p = 0.029).; (4) Conclusions: the evaluation of serotonin concentration predicts requirement for opioid pain relief medication. The polymorphisms of the serotonin receptors affect the intensity of postoperative complaints.
Keyphrases
- chronic pain
- pain management
- postoperative pain
- polycystic ovary syndrome
- copy number
- genome wide
- neuropathic pain
- patients undergoing
- genome wide identification
- minimally invasive
- high intensity
- physical activity
- gene expression
- emergency department
- dna methylation
- coronary artery disease
- spinal cord
- metabolic syndrome
- depressive symptoms
- insulin resistance
- transcription factor
- coronary artery bypass