Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study.

Tjokosela TikisoValentin FuhrmannChristina KönigDominik JarczakStefanie Iwersen-BergmannStefan KlugeSebastian G WichaJörn Grensemann

Published in: Annals of intensive care (2023)

Linezolid body clearance in ACLF was markedly lower than in NLF. Given the overall high variability, therapeutic drug monitoring (TDM) with dose adjustments seems required to optimize target attainment. Until TDM results are available, a dose reduction may be considered in ACLF patients to prevent overexposure.

Keyphrases

liver failure
end stage renal disease
chronic kidney disease
hepatitis b virus
peritoneal dialysis
ejection fraction
newly diagnosed
methicillin resistant staphylococcus aureus
drug induced
patient reported outcomes
respiratory failure
intensive care unit
patient reported