Deferasirox drives ROS-mediated differentiation and induces interferon-stimulated gene expression in human healthy haematopoietic stem/progenitor cells and in leukemia cells.
Tiziana TataranniCarmela MazzoccoliFrancesca AgriestiLuciana De LucaIlaria LaurenzanaVittorio SimeonVitalba RuggieriConsiglia PacelliGerardo Della SalaPellegrino MustoNazzareno CapitanioClaudia PiccoliPublished in: Stem cell research & therapy (2019)
These findings suggest a significant involvement of redox signalling as a major regulator of multiple DFX-orchestrated events promoting differentiation in healthy and tumour cells. The understanding of molecular mechanisms underlying the haematological response by DFX would enable to predict patient's ability to respond to the drug, to extend treatment to other patients or to anticipate the treatment, regardless of the iron overload.
Keyphrases
- induced apoptosis
- gene expression
- cell cycle arrest
- end stage renal disease
- cell death
- newly diagnosed
- acute myeloid leukemia
- chronic kidney disease
- dna damage
- emergency department
- bone marrow
- dendritic cells
- oxidative stress
- peritoneal dialysis
- cell proliferation
- prognostic factors
- signaling pathway
- combination therapy
- reactive oxygen species