Therapeutic effects of peripherally administrated neural crest stem cells on pain and spinal cord changes after sciatic nerve transection.

Yang ZhangXiang XuYuxin TongXijie ZhouJian DuIn Young ChoiShouwei YueGabsang LeeBlake N JohnsonXiaofeng Jia

Published in: Stem cell research & therapy (2021)

NCSC-laden nerve scaffolds mitigated SNT-induced neuropathic pain and improved motor function recovery after sciatic nerve repair. NCSCs also protected the spinal cord from SNT-induced glial activation and central sensitization.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
stem cells
high glucose
diabetic rats
chronic pain
oxidative stress
bone marrow
stress induced
postoperative pain