Login / Signup

Mean global DNA methylation serves as independent prognostic marker in IDH wild type glioblastoma.

Alicia EckhardtRichard DrexlerMelanie SchoofNina StruveDavid CapperClaudius JelgersmaJulia OnkenPatrick N HarterKatharina J WeberIris DivéKai RothkammKonstantin HofferLukas KlumppKatrin GanserCordula PetersenFranz L RicklefsMalte KriegsUlrich Schüller
Published in: Neuro-oncology (2023)
Our results indicate that mean global DNA methylation is independently associated with outcome in glioblastoma. The data also suggest that a higher DNA methylation is associated with better radiotherapy response and less aggressive phenotype, both of which presumably contribute to the observed correlation with OS.
Keyphrases
  • dna methylation
  • wild type
  • genome wide
  • gene expression
  • early stage
  • electronic health record
  • radiation therapy
  • radiation induced
  • big data
  • locally advanced
  • squamous cell carcinoma
  • machine learning