Expressions of glutathione S-transferase alpha, mu, pi, and theta in the skin samples of patients with acne rosacea.

In rosacea, the significant increase of GSTT1, GSTP1, and GSTM1 expressions might result from activation of GST as an outcome of extreme free radical generation from triggered neutrophils or ultraviolet vulnerability. These findings support the relevance of oxidant stress in the pathogenesis of rosacea.