Transcranial Blood-Brain Barrier Opening in Alzheimer's Disease Patients Using A Portable Focused Ultrasound System with Real-Time 2-D Cavitation Mapping.

Sua BaeKeyu LiuAntonios N Pouliopoulos Robin Ji Sergio Jiménez-Gambín Omid Yousefian Alina R Kline-Schoder Alec J Batts Danae Kokossis Akiva Mintz Lawrence S Honig Elisa E Konofagou

Published in: medRxiv : the preprint server for health sciences (2024)

Safety and feasibility of this cost-efficient and portable FUS for BBBO in AD patients were demonstrated with real-time mapping correlating with BBBO volume and a reduction in pathology, as well as serum detection of the AD proteins, Aβ and tau. Our study suggest the potential for accessible FUS treatment in AD, with or without drug delivery.

Keyphrases

blood brain barrier
end stage renal disease
drug delivery
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
high resolution
peritoneal dialysis
risk assessment
brain injury
mild cognitive impairment
high density
subarachnoid hemorrhage