Nuclear Medicine Imaging Tools in Fever of Unknown Origin: Time for a Revisit and Appropriate Use Criteria.
William F WrightSheetal KandiahRebecca BradyBarry L ShulkinChristopher J PalestroSanjay K JainPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2024)
Fever of unknown origin (FUO) is a clinical conundrum for patients and clinicians alike, and imaging studies are often performed as part of the diagnostic workup of these patients. Recently, the Society of Nuclear Medicine and Molecular Imaging convened and approved a guideline on the use of nuclear medicine tools for FUO. The guidelines support the use of 2-18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in adults and children with FUO. 18F-FDG PET/CT allows detection and localization of foci of hypermetabolic lesions with high sensitivity because of the 18F-FDG uptake in glycolytically active cells that may represent inflammation, infection, or neoplasia. Clinicians should consider and insurers should cover 18F-FDG PET/CT when evaluating patients with FUO, particularly when other clinical clues and preliminary studies are unrevealing.
Keyphrases
- positron emission tomography
- computed tomography
- end stage renal disease
- pet ct
- pet imaging
- newly diagnosed
- chronic kidney disease
- ejection fraction
- palliative care
- dual energy
- peritoneal dialysis
- prognostic factors
- magnetic resonance imaging
- oxidative stress
- contrast enhanced
- induced apoptosis
- case control
- endoplasmic reticulum stress
- fluorescence imaging