Gut microbiota-derived butyrate improved acute leptospirosis in hamster via promoting macrophage ROS mediated by HDAC3 inhibition.

Xi ChenXufeng XieNi SunXin LiuJiuxi LiuWenlong Zhang Yongguo Cao

Published in: mBio (2024)

by inhibiting HDAC3. This work confirms the therapeutic potential of butyrate in preventing acute leptospirosis and provides evidence for the benefits of the macrophage-HDAC3i-ROS axis.

Keyphrases

liver failure
histone deacetylase
respiratory failure
dna damage
cell death
adipose tissue
drug induced
aortic dissection
reactive oxygen species
signaling pathway
hepatitis b virus
oxidative stress
intensive care unit