Elevated CD21 low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency.

Peter BergmanDavid WullimannYu GaoEmilie Wahren BorgströmAnna-Carin NorlinSara Lind EnokssonSoo AlemanHans-Gustaf LjunggrenMarcus BuggertC I Edvard Smith

Published in: Journal of clinical immunology (2022)

B-cells according to the EUROclass definition demonstrated poor responses to Pfizer-BioNTech BNT162b2 mRNA vaccination. Cellular immune responses were significantly affected, affirming that the defect in CVID is not limited to humoral immunity.

Keyphrases

immune response
sars cov

binding protein
toll like receptor

dendritic cells

respiratory syndrome coronavirus