Deficient Chaperone-Mediated Autophagy in Macrophage Aggravates Inflammation of Nonalcoholic Steatohepatitis by Targeting Nup85.

Miao ZhangSiyuan TianShuoyi MaXia ZhouXiaohong ZhengBo LiGuanya GuoJiahao YuRui SuFangfang YangYinan HuGang MaHui YangLinhua ZhengChangcun GuoYulong ShangJingbo WangYing Han

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

We proposed that the impaired CMA-induced Nup85 degradation aggravated monocyte recruitment, promoting liver inflammation and disease progression of NASH.

Keyphrases

oxidative stress
diabetic rats
dendritic cells
cell death
adipose tissue
signaling pathway
endoplasmic reticulum stress
heat shock protein
peripheral blood