Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[ cd ]indole-2(1 H )-ketone.
Hongshuang QinLin LiShuhan ChenXuwei HanRunan MinYanxiang GuoTao LiuChuanqi ZhaoPublished in: Journal of materials chemistry. B (2024)
6-Nitrobenzo[ cd ]indole-2(1 H )-ketone (compound C2) exhibits an excellent germicidal effect against methicillin-resistant Staphylococcus aureus (MRSA). Mechanism studies show that C2 induces ROS over-production, cell membrane damage, and ATP and virulence factor down-regulation in bacteria. More importantly, C2 can inhibit biofilm formation and accelerate wound healing in a mouse infection model induced by MRSA.
Keyphrases
- staphylococcus aureus
- methicillin resistant staphylococcus aureus
- biofilm formation
- drug resistant
- multidrug resistant
- acinetobacter baumannii
- wound healing
- pseudomonas aeruginosa
- cell death
- escherichia coli
- dna damage
- nk cells
- candida albicans
- reactive oxygen species
- helicobacter pylori infection
- oxidative stress
- helicobacter pylori