Effect of Pulsed Low-Level Lasers on Adult versus Neonatal Human Retinal Pigment Epithelial Cells: An in-vitro Study.

Seyed Mohamadmehdi MoshtaghionMohammad AbolhosseiniFaraj TabeieSahar BalagholiFatemeh SuriSamira KaramiHoura NaraghiMozhgan Rezaei KanaviSomayeh Asadi

Published in: Journal of ophthalmic & vision research (2024)

Short-term irradiation of neonatal and adult hRPE cells with LLLs may induce multipotency at the transcriptional level. Irradiation of neonatal hRPE cells with LLLs can be associated with increased risk of myofibroblastic transformation; however, adult hRPE cells irradiated with the 780 nm laser have minimal risk of myofibroblastic differentiation. It seems that the 780 nm laser may be a promising option for future photobiomodulation in retinal degenerations in adults.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
gene expression
signaling pathway
high speed
current status
childhood cancer