Divergent effect of Birinapant, and BV6 SMAC mimetic on TNFα induced NF-κB signaling and cell viability in activated hepatic stellate cells.
Shaikh Maryam GhufranSachin SharmaSampa GhoseSubhrajit BiswasPublished in: Molecular biology reports (2022)
In this study, we describe the regulatory role of cIAP2 in TNFα induced NF-κB signaling in activated HSCs. Targeting cIAP2 may be a promising approach for liver fibrosis treatment via modulating NF-κB signaling in activated HSCs.
Keyphrases
- signaling pathway
- lps induced
- liver fibrosis
- induced apoptosis
- high glucose
- oxidative stress
- diabetic rats
- pi k akt
- rheumatoid arthritis
- nuclear factor
- inflammatory response
- cell cycle arrest
- drug induced
- endothelial cells
- transcription factor
- lipopolysaccharide induced
- cancer therapy
- drug delivery
- toll like receptor
- combination therapy
- smoking cessation