Intensity-Modulated Radiotherapy (IMRT) following Conservative Surgery of the Supraglottic Region: Impact on Functional Outcomes.
Daniela AlterioSimona MaraniValeria ZurloStefano Filippo ZorziAnnamaria FerrariStefania VolpeFrancesco BandiSabrina VigoritoMaria Giulia VinciniSara GandiniAurora GaetaCristiana Iuliana FodorAlessia CasbarraMattia ZaffaroniAnna StarzyńskaLiliana BelgioiaMohssen AnsarinCynthia AristeiBarbara Alicja Jereczek-FossaPublished in: Cancers (2022)
The aim of the present study was to investigate the role of intensity-modulated radiotherapy (IMRT) on the toxicity profile of patients treated with conservative surgery (CS) of the supraglottic (SG) region. Data on patients treated with CS and postoperative radiotherapy (PORT)-IMRT were prospectively collected. Results. In total, 20 patients were analyzed. Of these, six patients (35%) required the positioning of a temporary tracheostomy. The functional larynx preservation rate was 95%. Females had a higher risk of both endoscopic intervention and chondronecrosis, while the median age was significantly higher in patients requiring enteral nutrition. The incidence of long-term severe toxicities was lower in patients treated with IMRT than in the historical 3D-CRT cohort. Patients who had received PORT-IMRT achieved a lower rate of permanent laryngeal and swallowing dysfunctions. Overall, results from the comparison with the historical 3D-CRT cohort favor the IMRTs.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- early stage
- minimally invasive
- heart failure
- coronary artery disease
- machine learning
- oxidative stress
- physical activity
- coronary artery bypass
- early onset
- electronic health record
- atrial fibrillation
- cardiac resynchronization therapy
- robot assisted
- ultrasound guided