Color Tuning of Fluorogens for FAST Fluorogen-Activating Protein.

Ivan N MyasnyankoAlexey S GavrikovSnizhana O ZaitsevaAlexander Yu SmirnovElvira R ZaitsevaAnatolii I SokolovKseniya K MalyshevskayaNadezhda S BaleevaAlexander S MishinMikhail S Baranov

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2021)

Using benzylidene imidazolone core, we created a panel of color-shifted fluorogenic ligands for FAST protein without compromise to the binding efficiency and the utility for live-cell protein labeling. This study highlights the potential of benzylidene imidazolones derivatives for rapid expansion of a pallet of live-cell fluorogenic labeling tools.

Keyphrases

binding protein
protein protein
amino acid
risk assessment
climate change