Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy.

Chia-Sing LuChing-Wen LinYa-Hsuan ChangHsuan-Yu ChenWei-Chia ChungWei-Yun LaiChao-Chi HoTong-Hong WangChi-Yuan ChenChen-Lin YehSean WuShu-Ping WangPan-Chyr Yang

Published in: Journal for immunotherapy of cancer (2021)

Our findings reveal novel mechanisms showing that pemetrexed upregulates PD-L1 expression and primes a favorable microenvironment for ICB, which provides a mechanistic basis for the combinatory chemoimmunotherapy in NSCLC treatment.

Keyphrases

small cell lung cancer
advanced non small cell lung cancer
stem cells
brain metastases
genome wide
epidermal growth factor receptor
single cell
dna methylation
mesenchymal stem cells