Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy.
Katri SilvennoinenNikola de LangeSara ZagagliaSimona BalestriniGanna AndrosovaMerel WassenaarPauls AuceAndreja AvbersekFelicitas BeckerBianca BerghuisEllen CampbellAntonietta CoppolaBen FrancisStefan WolkingGianpiero L CavalleriJohn CraigNorman DelantyMichael R JohnsonBobby P C KoelemanWolfram S KunzHolger LercheAnthony G MarsonTerence J O'BrienJosemir W SanderGraeme J SillsPasquale StrianoFederico ZaraJob van der PalenRoland KrauseChantal DepondtSanjay M Sisodiyanull nullPublished in: Epilepsia open (2019)
In people with JME, valproate is an effective AED; levetiracetam emerged as an alternative. Valproate is now contraindicated in women of childbearing potential without special precautions. With appropriate selection and safeguards in place, valproate should remain available as a therapy, including as an alternative for women of childbearing potential whose seizures are resistant to other treatments.