Histopathological Myocardial Changes in Patients with Severe Aortic Stenosis Referred for Surgical Valve Replacement: A CMR Correlation Study.

João AbecasisPedro LopesSergio MaltesRita Reis SantosAntónio FerreiraRegina RibeirasMaria João AndradeMiguel Sousa UvaVictor GilAna FélixSancia RamosNuno Cardim

Published in: European heart journal. Cardiovascular Imaging (2024)

patients with severe symptomatic AS referred for surgical AVR have unspecific histological myocardial changes, including signs of cardiomyocyte ischemic insult. ECM remodeling is ongoing, with MF heterogeneity. These features may be recognized by comprehensive CMR protocols. However, no single CMR parameter captures the burden of MF and histological myocardial changes in this setting.

Keyphrases

aortic stenosis
left ventricular
aortic valve
transcatheter aortic valve replacement
aortic valve replacement
ejection fraction
transcatheter aortic valve implantation
mitral valve
early onset
heart failure
coronary artery disease
single cell
angiotensin ii
extracellular matrix
drug induced
endothelial cells