The dual pro-inflammatory and bone-protective role of calcitonin gene-related peptide alpha in age-related osteoarthritis.
Alexander HildebrandtTamara DietrichJérôme WeberMara Meyer GünderothSijia ZhouFlorian Nima FleckensteinShan JiangTobias WinklerGeorg N DudaSerafeim TsitsilonisJohannes KellerTazio MaleitzkePublished in: Arthritis research & therapy (2023)
Similar to its function in experimental RA, αCGRP exerts a dual pro-inflammatory and bone-protective function in murine primary OA. Although anti-CGRP treatment was previously not successful in reducing pain in OA clinically, these data underline a crucial pathophysiological role of αCGRP in age-related OA.
Keyphrases
- knee osteoarthritis
- bone mineral density
- rheumatoid arthritis
- chronic pain
- soft tissue
- bone loss
- bone regeneration
- pain management
- genome wide
- electronic health record
- postmenopausal women
- gene expression
- big data
- spinal cord
- combination therapy
- deep learning
- idiopathic pulmonary fibrosis
- genome wide identification
- drug induced
- data analysis