Impaired Bidirectional Synaptic Plasticity in Juvenile Offspring Following Prenatal Ethanol Exposure.

Christine J FontaineCristina PinarWaisley YangAngela F PangKonrad E SuesserJames S J ChoiBrian R Christie

Published in: Alcoholism, clinical and experimental research (2019)

These data are the first to describe, in a single study, the impact of PNEE on the dynamic range of bidirectional synaptic plasticity in the juvenile DG in both males and in females. The data suggest that PNEE increases the threshold for LTP in the DG in both sexes, but produces a sex-specific increase in the threshold for LTD in males These alterations reduce the dynamic range for synaptic plasticity in both sexes.

Keyphrases

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