Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma.
Mustafa KhasrawMichael WellerDavid Lorente EstellésKathryn KolibabaChee Khoon LeeCraig GedyeMacarena I de La FuenteDavid VicenteDavid A ReardonHui K GanAndrew M ScottIsabelle DussaultChristoph HelwigLaureen S OjalvoCarole GourmelonMorris GrovesPublished in: Neuro-oncology advances (2021)
The percentage of patients achieving disease control and the manageable safety profile may warrant further investigation of bintrafusp alfa in GBM.