Decrease in CD38+ TH2A cell frequencies following immunotherapy with house dust mite tablet correlates with humoral responses.

Sonia LuceThierry BatardVéronique Bordas-Le FlochMartine Le GallLaurent Mascarell

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)

We confirm the value of monitoring TH2A cell frequencies in allergic individuals and extend this observation to perennial allergy to HDM. We highlight the interest of CD38 to better identify the subset of TH2A cell down-regulated by AIT. Finally, correlated cellular and humoral responses observed in immunoreactive individuals stress that coordinated pathways occur in the adaptive responses during AIT.

Keyphrases

single cell
immune response
cell therapy
stem cells
mesenchymal stem cells
climate change
heavy metals