Utility of Cerebrospinal Fluid Protein Levels as a Potential Predictive Biomarker of Disease Severity in HIV-Associated Cryptococcal Meningitis.
John KasibanteEesha IrfanullahAbduljewad WeleElizabeth C OkaforKenneth SsebambuliddeSamuel OkurutEnock KagimuJane GakuruMorris K RutakingirwaTimothy MugabiEdwin NuwagiraSamuel JjunjuEdward MpozaLillian TugumeLaura NsangiAbdu K MusibireConrad MuzooraJoshua RheinDavid B MeyaDavid R BoulwareMahsa AbassiPublished in: medRxiv : the preprint server for health sciences (2023)
In cryptococcal meningitis, individuals with CSF protein ≥100 mg/dL more frequently presented with seizures, altered mental status, immune activation, and favourable fungal outcomes. Baseline CSF protein levels may serve as a surrogate marker of immune activation and prognosis.